Artemisinin-dipeptidyl vinyl sulfone hybrid molecules

A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium fa...

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Bibliographic Details
Main Author: Capela, Rita (author)
Other Authors: Oliveira, Rudi (author), Goncalves, Lidia M. (author), Domingos, Ana (author), Gut, Jiri (author), Rosenthal, Philip J. (author), Lopes, Francisca (author), Moreira, Rui (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Medicinal
Chemistry, Organic
Online Access:http://hdl.handle.net/10451/21198
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21198

Internet

http://hdl.handle.net/10451/21198

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