Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting

BACKGROUND: Multidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) presents a challenge to disease control and elimination goals. In Lisbon, Portugal, specific and successful XDR-TB strains have been found in circulation for almost two decades. RESULTS: In the present study we have...

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Bibliographic Details
Main Author: Perdigão, João (author)
Other Authors: Silva, Hugo (author), Machado, Diana (author), Macedo, Rita (author), Maltez, Fernando (author), Silva, Carla (author), Jordao, Luisa (author), Couto, Isabel (author), Mallard, Kim (author), Coll, Francesc (author), Hill-Cawthorne, Grant A (author), McNerney, Ruth (author), Pain, Arnab (author), Clark, Taane G (author), Viveiros, Miguel (author), Portugal, Isabel (author)
Format: article
Language:eng
Published: 2021
Subjects:
Antitubercular Agents
Bacterial Proteins
Chromosome Mapping
Computational Biology
Drug Resistance, Multiple, Bacterial
Evolution, Molecular
Genetic Loci
Genetic Variation
Genome, Bacterial
Genomic Instability
Genomics
Genotype
Humans
INDEL Mutation
Microbial Sensitivity Tests
Minisatellite Repeats
Mycobacterium tuberculosis
Phylogeny
Polymorphism, Single Nucleotide
Portugal
Tuberculosis, Multidrug-Resistant
Journal Article
Research Support, Non-U.S. Gov't
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Microbiology
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/116810
Country:Portugal
Oai:oai:run.unl.pt:10362/116810

Internet

http://hdl.handle.net/10362/116810

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