Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats

Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicity, which has a preponderant mitochondrial componen...

Full description

Bibliographic Details
Main Author: Pereira, Gonçalo Castro (author)
Other Authors: Pereira, Susana P (author), Pereira, Francisco B (author), Lourenço, Nuno António Marques (author), Lumini, José A (author), Pereira, Cláudia V. (author), Bjork, James A. (author), Magalhães, José (author), Ascensão, António (author), Wieckowski, Mariusz R. (author), Moreno, António J (author), Wallace, Kendall B. (author), Oliveira, Paulo J (author)
Format: article
Language:por
Published: 2019
Subjects:
animal study; cardiotoxicity; doxorubicin; feature correlation analysis; mitochondrial permeability transition; principal component analysis
Animals
Antibiotics, Antineoplastic
Calcium
Cardiotoxicity
Cell Respiration
Doxorubicin
Electron Transport Chain Complex Proteins
Heart Diseases
Hydrogen Peroxide
Male
Mitochondria, Heart
Myocytes, Cardiac
Rats, Wistar
Time Factors
Online Access:http://hdl.handle.net/10316/101008
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/101008

Internet

http://hdl.handle.net/10316/101008

Similar Items