Coadministration of antiepileptic drugs and P-glycoprotein inhibitors of flavonoid-type
The resistance to antiepileptic drugs (AEDs) remains a major unsolved therapeutic problem, which affects 30-40% of patients with epilepsy. The overexpression of multidrug efflux transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggest...
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| Format: | doctoralThesis |
| Language: | eng |
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2018
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| Online Access: | http://hdl.handle.net/10400.6/4775 |
| Country: | Portugal |
| Oai: | oai:ubibliorum.ubi.pt:10400.6/4775 |