Dipeptide derivatives of AZT

5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were evaluated for their stability at pH 74 in buffer and in human plasma, affinity toward hPEPT1, cytotoxicity, and antiretroviral activity. The dipept...

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Detalhes bibliográficos
Autor principal: Santos, Cledir (author)
Outros Autores: Morais, Jose (author), Gouveia, Luis (author), de Clercq, Erik (author), Pannecouque, Christophe (author), Nielsen, Carsten Uhd (author), Steffansen, Bente (author), Moreira, Rui (author), Gomes, Paula (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Chemistry, Medicinal
Pharmacology & Pharmacy
Texto completo:http://hdl.handle.net/10451/21282
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21282

Texto Completo

http://hdl.handle.net/10451/21282

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