Dipeptide derivatives of AZT

5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were evaluated for their stability at pH 74 in buffer and in human plasma, affinity toward hPEPT1, cytotoxicity, and antiretroviral activity. The dipept...

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Bibliographic Details
Main Author: Santos, Cledir (author)
Other Authors: Morais, Jose (author), Gouveia, Luis (author), de Clercq, Erik (author), Pannecouque, Christophe (author), Nielsen, Carsten Uhd (author), Steffansen, Bente (author), Moreira, Rui (author), Gomes, Paula (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Medicinal
Pharmacology & Pharmacy
Online Access:http://hdl.handle.net/10451/21282
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21282

Internet

http://hdl.handle.net/10451/21282

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