Therapeutic l-asparaginase: upstream, downstream and beyond

L-asparaginase (L-asparagine amino hydrolase, E.C.3.5.1.1) is an enzyme clinically accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma. It catalyzes L-asparagine (Asn) hydrolysis to L-aspartate and ammonia, and Asn effective depletion results in cytotoxicity to leu...

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Bibliographic Details
Main Author: Lopes, Andre Moreni (author)
Other Authors: Oliveira-Nascimento, Laura de (author), Ribeiro, Artur (author), Tairum Jr, Carlos Abrunhosa (author), Breyer, Carlos Alexandre (author), Oliveira, Marcos Antonio de (author), Monteiro, Gisele (author), Souza-Motta, Cristina Maria de (author), Magalhães, Pérola de Oliveira (author), Avendaño, Jorge Gonzalo Farías (author), Cavaco-Paulo, Artur (author), Mazzola, Priscila Gava (author), Rangel-Yagui, Carlota de Oliveira (author), Sette, Lara Durães (author), Converti, Attilio (author), Pessoa, Adalberto (author)
Format: article
Language:eng
Published: 2017
Subjects:
Acute lymphoblastic leukemia
antineoplastic activity
biopharmaceutical
l-asparaginase
microbial l-asparaginase production
Science & Technology
Online Access:http://hdl.handle.net/1822/43886
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/43886

Internet

http://hdl.handle.net/1822/43886

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