Patterns of mitochondrial DNA damage in blood and brain tissues of a transgenic mouse model of Machado-Joseph disease

BACKGROUND: Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia caused by a CAG tract expansions in the ATXN3 gene. Patterns of mitochondrial damage associated with pathological findings of brain tissues could provide molecular biomarkers of this disorder. OBJECTIVE: The pot...

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Bibliographic Details
Main Author: Kazachkova, Nadiya (author)
Other Authors: Raposo, Mafalda (author), Montiel, Rafael (author), Cymbron, Teresa (author), Bettencourt, Conceição (author), Fernandes, Anabela Silva (author), Silva, Sara Carina Duarte (author), Maciel, P. (author), Lima, Manuela (author)
Format: article
Language:eng
Published: 2013
Subjects:
Mitochondrial DNA
Mitochondrial DNA copy number and deletion
3,867-bp deletion
Machado-Joseph disease
SCA3
CAG repeats
Ataxin-3
Neurodegenerative disorder
Polyglutamine disorder
Transgenic mouse model
Science & Technology
Online Access:http://hdl.handle.net/1822/26940
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/26940

Internet

http://hdl.handle.net/1822/26940

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