Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors

The synthesis and the biological activity of compounds 5-40 as inhibitors of acetyleholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca2+ channels and nicotinic receptors, are described. These molecules are tacrine analogues, which have been prepared...

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Bibliographic Details
Main Author: Marco, JL (author)
Other Authors: de los Rios, C (author), Garcia, AG (author), Villarroya, M (author), Carreiras, MC (author), Martins, C (author), Eleuterio, A (author), Morreale, A (author), Orozco, M (author), Luque, FJ (author)
Format: article
Language:eng
Published: 2015
Subjects:
Biochemistry & Molecular Biology
Chemistry, Medicinal
Chemistry, Organic
Online Access:http://hdl.handle.net/10451/21381
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21381

Internet

http://hdl.handle.net/10451/21381

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