Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells

A major risk factor promoting tumor development is chronic inflammation and the use of nonsteroidal anti-inflammatory drugs (NSAID), including ibuprofen, can decrease the risk of developing various types of cancer, including colorectal cancer (CRC). Although the molecular mechanism behind the antitu...

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Detalhes bibliográficos
Autor principal: Gonçalves, Vânia (author)
Outros Autores: Henriques, Andreia F.A. (author), Matos, Paulo (author), Jordan, Peter (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Ibuprofen
RAC1B
Alternative Splicing
Colorectal Cancer Cells
Protein Kinase
Vias de Transdução de Sinal e Patologias Associadas
Cancro Colorectal
splicing Alternativo
Texto completo:http://hdl.handle.net/10400.18/7498
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7498

Texto Completo

http://hdl.handle.net/10400.18/7498

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