Cyclization-activated prodrugs
Many drugs suffer from an extensive first-pass metabolism leading to drug inactivation and/or production of toxic metabolites, which makes them attractive targets for prodrug design. The classical prodrug approach, which involves enzyme-sensitive covalent linkage between the parent drug and a carrie...
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| Outros Autores: | , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2007
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| Assuntos: | |
| Texto completo: | https://hdl.handle.net/10216/82101 |
| País: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/82101 |