Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

This work proposes the design of nanoparticles based on locus bean gum (LBG) and chitosan to be used as oral immunoadjuvant for vaccination purposes. LBG-based nanoparticles were prepared by mild polyelectrolyte complexation between chitosan (CS) and a synthesized LBG sulfate derivative (LBGS). Morp...

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Bibliographic Details
Main Author: Braz, L. (author)
Other Authors: Grenha, Ana (author), Ferreira, Domingos (author), Rosa Da Costa, Ana (author), Gamazo, Carlos (author), Sarmento, Bruno (author)
Format: article
Language:eng
Published: 2019
Subjects:
Polyelectrolyte complex nanoparticles
Loaded chitosan nanoparticles
Vaccine delivery
Immune-response
Salmonella-enteritidis
Hepatitis-B
Chitosan/Carrageenan nanoparticles
Immunoadjuvant properties
Bioadhesive capacity
Protein delivery
Online Access:http://hdl.handle.net/10400.1/13217
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13217

Internet

http://hdl.handle.net/10400.1/13217

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