Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback

Sister chromatid cohesion, mediated by the cohesin complex, is essential for faithful mitosis. Nevertheless, evidence suggests that the surveillance mechanism that governs mitotic fidelity, the spindle assembly checkpoint (SAC), is not robust enough to halt cell division when cohesion loss occurs pr...

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Detalhes bibliográficos
Autor principal: Mirkovic, Mihailo (author)
Outros Autores: Hutter, Lukas H. (author), Novák, Béla (author), Oliveira, Raquel A. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Sister chromatid separation
Drosophila
SAC
mitosis
Texto completo:http://hdl.handle.net/10400.7/657
País:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/657

Texto Completo

http://hdl.handle.net/10400.7/657

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