Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides

Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic featur...

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Bibliographic Details
Main Author: Brango-Vanegas, J (author)
Other Authors: Martinho, L (author), Bessa, L (author), Vasconcelos, A (author), Plácido, A (author), Pereira, A (author), Leite, J (author), Machado, A (author)
Format: article
Language:eng
Published: 2019
Subjects:
Antivirulence drug
Bacteria
Macrocyclization
Pathoblocker
Quorum quenching
Online Access:https://hdl.handle.net/10216/136274
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/136274

Internet

https://hdl.handle.net/10216/136274

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