Evidence for a Myotomal Hox/Myf Cascade Governing Nonautonomous Control of Rib Specification within Global Vertebral Domains

Hox genes are essential for the patterning of the axial skeleton. Hox group 10 has been shown to specify the lumbar domain by setting a rib-inhibiting program in the presomitic mesoderm (PSM). We have now produced mice with ribs in every vertebra by ectopically expressing Hox group 6 in the PSM, ind...

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Bibliographic Details
Main Author: Vinagre, Tânia (author)
Other Authors: Moncaut, Natalia (author), Carapuço, Marta (author), Nóvoa, Ana (author), Bom, Joana (author), Mallo, Moisés (author)
Format: article
Language:eng
Published: 2016
Subjects:
Animals
Bone Development
Fibroblast Growth Factors
Homeodomain Proteins
Mice
Mice, Transgenic
Models, Biological
Models, Genetic
Muscle Development
Myogenic Regulatory Factor 5
Myogenic Regulatory Factors
Phenotype
Platelet-Derived Growth Factor
Gene Expression Regulation, Developmental
Online Access:http://hdl.handle.net/10400.7/669
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/669

Internet

http://hdl.handle.net/10400.7/669

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