Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice

Thymic epithelial cells (TECs) provide crucial microenvironments for T-cell development and tolerance induction. As the regular function of the thymus declines with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo. Beyond its recogniz...

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Detalhes bibliográficos
Autor principal: Rodrigues, PM (author)
Outros Autores: Ribeiro, AR (author), Perrod, C (author), Landry, JJM (author), Araújo, L (author), Pereira-Castro, I (author), Benes, V (author), Moreira, A (author), Xavier-Ferreira, H (author), Meireles, C (author), Alves, NL (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Animals
Cell Differentiation/genetics
Cell Differentiation/immunology
Epithelial Cells/cytology
Epithelial Cells/immunology
Mice
Mice Knockout
T-Lymphocytes Regulatory/cytology
T-Lymphocytes Regulatory/immunology
Thymocytes/cytology
Thymocytes/immunology
Thymus Gland
Tumor Suppressor Protein p53/genetics
Tumor Suppressor Protein p53/immunology
Texto completo:http://hdl.handle.net/10216/110346
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110346

Texto Completo

http://hdl.handle.net/10216/110346

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