Thymic epithelial cells require p53 to support their long-term function in thymopoiesis in mice

Thymic epithelial cells (TECs) provide crucial microenvironments for T-cell development and tolerance induction. As the regular function of the thymus declines with age, it is of fundamental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo. Beyond its recogniz...

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Bibliographic Details
Main Author: Rodrigues, PM (author)
Other Authors: Ribeiro, AR (author), Perrod, C (author), Landry, JJM (author), Araújo, L (author), Pereira-Castro, I (author), Benes, V (author), Moreira, A (author), Xavier-Ferreira, H (author), Meireles, C (author), Alves, NL (author)
Format: article
Language:eng
Published: 2017
Subjects:
Animals
Cell Differentiation/genetics
Cell Differentiation/immunology
Epithelial Cells/cytology
Epithelial Cells/immunology
Mice
Mice Knockout
T-Lymphocytes Regulatory/cytology
T-Lymphocytes Regulatory/immunology
Thymocytes/cytology
Thymocytes/immunology
Thymus Gland
Tumor Suppressor Protein p53/genetics
Tumor Suppressor Protein p53/immunology
Online Access:http://hdl.handle.net/10216/110346
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110346

Internet

http://hdl.handle.net/10216/110346

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