Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

Imidazolidin-4-one derivatives of primaquine were synthesized as potential double prodrugs of the parent drug. The title compounds inhibit the development of the sporogonic cycle of Plasmodium berghei, affecting the appearance of oocysts in the midguts of the mosquitoes. The imidazolidin-4-ones are...

Full description

Bibliographic Details
Main Author: Araujo, MJ (author)
Other Authors: Bom, J (author), Capela, R (author), Casimiro, C (author), Chambel, P (author), Gomes, P (author), Iley, J (author), Lopes, F (author), Morais, J (author), Moreira, R (author), de Oliveira, E (author), do Rosario, V (author), Vale, N (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Medicinal
Online Access:http://hdl.handle.net/10451/21195
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21195

Internet

http://hdl.handle.net/10451/21195

Similar Items