The role of poly(ADP-ribose)polymerase in the induction of sister chromatid exchanges and micronuclei by mitomycin C in Down's syndrome cells as compared to euploid cells

Inhibitors of poly(ADP-ribose)polymerase (PARP; EC 2.4.2.30), such as 3-aminobenzamide (3-AB), can be used to assess the role of the enzyme in the induction of DNA lesions in euploid cells as compared to cells of genetic conditions known to exhibit increased susceptibility to chemical or physical mu...

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Bibliographic Details
Main Author: Caria, Helena (author)
Other Authors: Quintas, Ana (author), Chaveca, Teresa (author), Rueff, José (author)
Format: article
Language:eng
Published: 2017
Subjects:
Down syndrome
Poly(ADP-ribose)poiymerase
Sister chromatid exchanges
Micronucleus;
Mitomycin C
Online Access:http://hdl.handle.net/10451/28687
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/28687

Internet

http://hdl.handle.net/10451/28687

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