Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

BACKGROUND & AIMS: The liver, being the major site of iron storage, is particularly exposed to the toxic effects of iron. Transcription factor NRF2 is critical for protecting the liver against disease by activating the transcription of genes encoding detoxification/antioxidant enzymes. We aimed...

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Bibliographic Details
Main Author: Silva-Gomes, S (author)
Other Authors: Santos, AG (author), Caldas, C (author), Silva, CM (author), Neves, JV (author), Lopes, J (author), Carneiro, F (author), Rodrigues, PN (author), Duarte, TL (author)
Format: article
Language:eng
Published: 2014
Subjects:
Animals
Antioxidants/pharmacology
Cyclic N-Oxides/pharmacology
Disease Models, Animal
Hepatocytes/drug effects
Hepatocytes/metabolism
Hepatocytes/pathology
Iron Overload/drugtherapy
Iron Overload/metabolism
Iron Overload/pathology
Iron Dietary/toxicity
Liver/injuries
Liver/metabolism
Liver/pathology
Male
Mice
Mice Inbred C57BL
Mice Knockout
Mitochondria Liver/drug effects
Mitochondria Liver/metabolism
NF-E2-Related Factor 2/deficiency
NF-E2-Related Factor 2/genetics
NF-E2-Related Factor 2/metabolism
Spin Labels
Online Access:http://hdl.handle.net/10216/110349
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110349

Internet

http://hdl.handle.net/10216/110349

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