Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection

Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of HO-1 expression in macrophages (M) is strictl...

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Bibliographic Details
Main Author: Silva-Gomes, Sandro (author)
Other Authors: Appelberg, Rui (author), Larsen, Rasmus (author), Soares, Miguel Parreira (author), Gomes, Maria Salomé (author)
Format: article
Language:eng
Published: 2015
Subjects:
Heme
heme oxygenase-1
Disease Resistance
Mycobacterium infection
Tuberculosis
Online Access:http://hdl.handle.net/10400.7/480
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/480

Internet

http://hdl.handle.net/10400.7/480

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