Targeting the proteasome in anticancer therapy by a computational based drug discovery approach

The ubiquitin-proteasome system plays an important role in cellular homeostasis and also has a critical role in regulating a wide variety of cellular pathways, including cell growth and proliferation, apoptosis, DNA repair and transcription. The proteasome is an essential multicatalytic protease tha...

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Bibliographic Details
Main Author: Guedes, Romina (author)
Format: doctoralThesis
Language:eng
Published: 2020
Subjects:
ubiquitin-proteasome system
proteasome
proteasome inhibitors
virtual screening
chemical patterns
Domínio/Área Científica::Ciências Médicas::Medicina Básica
Online Access:http://hdl.handle.net/10451/42785
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/42785

Internet

http://hdl.handle.net/10451/42785

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