Targeting the proteasome in anticancer therapy by a computational based drug discovery approach
The ubiquitin-proteasome system plays an important role in cellular homeostasis and also has a critical role in regulating a wide variety of cellular pathways, including cell growth and proliferation, apoptosis, DNA repair and transcription. The proteasome is an essential multicatalytic protease tha...
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| Formato: | doctoralThesis |
| Idioma: | eng |
| Publicado em: |
2020
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| Texto completo: | http://hdl.handle.net/10451/42785 |
| País: | Portugal |
| Oai: | oai:repositorio.ul.pt:10451/42785 |