Functional and conformational changes in the aspartic protease cardosin A induced by TFE

Conformational and functional changes of cardosin A, an aspartic protease of vegetal origin, in the presence of 2,2,2-trifluoroethanol (TFE), were assessed. TFE induced alterations of cardosin activity and conformation that differed with the solvent concentration. MD simulations showed that there ar...

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Bibliographic Details
Main Author: Fraga, Ana Sofia (author)
Other Authors: Esteves, Ana Cristina (author), Micaelo, Nuno (author), Cruz, Pedro F. (author), Brito, Rui M. M. (author), Nutley, Margaret (author), Cooper, Alan (author), Barros, Marlene M. T. (author), Pires, Euclides M. V. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Aspartic proteases
Trifluoroethanol
Circular dichroism
Calorimetry
Molecular dynamics simulations
Online Access:http://hdl.handle.net/10773/26797
Country:Portugal
Oai:oai:ria.ua.pt:10773/26797

Internet

http://hdl.handle.net/10773/26797

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