The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Targeting multiple cellular populations is of high therapeutic relevance for the tackling of solid tumors heterogeneity. Herein, the ability of pegylated and pH-sensitive liposomes, functionalized with the nucleolin-binding F3 peptide and containing doxorubicin (DXR)/C6-ceramide synergistic combinat...

ver descrição completa

Detalhes bibliográficos
Autor principal: Cruz, Ana F. (author)
Outros Autores: Caleiras, Mariana B. (author), Fonseca, Nuno A. (author), Gonçalves, Nélio (author), Mendes, Vera M. (author), Sampaio, Susana F. (author), Moura, Vera (author), Melo, Joana B. (author), Almeida, Ramiro D. (author), Manadas, Bruno (author), Simões, Sérgio Paulo (author), Moreira, João N. (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
nucleolin
ovarian cancer
doxorubicin
C6-ceramide
synergistic combination
phospho-Akt downregulation
Texto completo:http://hdl.handle.net/10316/103812
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103812

Texto Completo

http://hdl.handle.net/10316/103812

Registos relacionados