Assembling human Platelet Lysate into multiscale 3D scaffolds for bone tissue engineering
Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-...
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| Outros Autores: | , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2015
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| Assuntos: | |
| Texto completo: | http://hdl.handle.net/1822/31545 |
| País: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/31545 |
| Resumo: | Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules. |
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