Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity

5'-O-Dipeptide ester prodrugs of antiviral zidovudine (AZT) were designed to target the human intestinal oligopeptide transporter, hPEPT1, and were evaluated for their stability at pH 74 in buffer and in human plasma, affinity toward hPEPT1, cytotoxicity, and antiretroviral activity. The dipept...

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Detalhes bibliográficos
Autor principal: Cledir Santos (author)
Outros Autores: Jose Morais (author), Luis Gouveia (author), Erik de Clercq (author), Christophe Pannecouque (author), Carsten Uhd Nielsen (author), Bente Steffansen (author), Rui Moreira (author), Paula Gomes (author)
Formato: article
Idioma:eng
Publicado em: 2008
Assuntos:
Medicina básica
Basic medicine
Texto completo:https://hdl.handle.net/10216/82105
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/82105

Texto Completo

https://hdl.handle.net/10216/82105

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