The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation

In humans, allelic variants in Toll-like receptors (TLRs) associate with several pathologies. However, the underlying cellular and molecular mechanisms of this association remain largely unknown. Analysis of the human TLR9 promoter revealed that the C allele of the rs5743836 polymorphism generates s...

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Bibliographic Details
Main Author: Carvalho, Agostinho (author)
Other Authors: Osório, Nuno S. (author), Saraiva, Margarida (author), Cunha, Cristina (author), Almeida, A. J. (author), Coelho, Maria Teixeira (author), Ludovico, Paula (author), Pedrosa, Jorge (author), Pitzurra, Lucia (author), Aversa, Franco (author), Romani, Luigina (author), Castro, António G. (author), Rodrigues, Fernando José dos Santos (author)
Format: article
Language:eng
Published: 2011
Subjects:
Allelic variants
Toll-like receptors (TLRs)
Human TLR9 promoter
rs5743836 polymorphism
IL-6-responding element
B-cell proliferation
TLR9 agonists
TLR9 antagonists
Science & Technology
Online Access:http://hdl.handle.net/1822/18618
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/18618

Internet

http://hdl.handle.net/1822/18618

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