Bi-allelic Mutations in M1AP Are a Frequent Cause of Meiotic Arrest and Severely Impaired Spermatogenesis Leading to Male Infertility

Male infertility affects ∼7% of men, but its causes remain poorly understood. The most severe form is non-obstructive azoospermia (NOA), which is, in part, caused by an arrest at meiosis. So far, only a few validated disease-associated genes have been reported. To address this gap, we performed whol...

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Bibliographic Details
Main Author: Wyrwoll, Margot J. (author)
Other Authors: Temel, Şehime G. (author), Nagirnaja, Liina (author), Oud, Manon S. (author), Lopes, Alexandra M. (author), van der Heijden, Godfried W. (author), Heald, James S. (author), Rotte, Nadja (author), Wistuba, Joachim (author), Wöste, Marius (author), Ledig, Susanne (author), Krenz, Henrike (author), Smits, Roos M. (author), Carvalho, Filipa (author), Gonçalves, João (author), Fietz, Daniela (author), Türkgenç, Burcu (author), Ergören, Mahmut C. (author), Çetinkaya, Murat (author), Başar, Murad (author), Kahraman, Semra (author), McEleny, Kevin (author), Xavier, Miguel J. (author), Turner, Helen (author), Pilatz, Adrian (author), Röpke, Albrecht (author), Dugas, Martin (author), Kliesch, Sabine (author), Neuhaus, Nina (author), Aston, Kenneth I. (author), Conrad, Donald F. (author), Veltman, Joris A. (author), Friedrich, Corinna (author), Tüttelmann, Frank (author)
Format: article
Language:eng
Published: 2021
Subjects:
Azoospermia
Cell Cycle Checkpoints
MaleI Infertility
Non-obstructive azoospermia (NOA)
Phenotype
Spermatogenesis
Spermatozoa
M1AP
Doenças Genéticas
Online Access:http://hdl.handle.net/10400.18/7354
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/7354

Internet

http://hdl.handle.net/10400.18/7354

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