Synthesis of tacrine analogues derived from n-aryl-5-amino-4-cyanopyrazoles

Synthesis of eleven tacrine analogues derived from N-aryl-5-amino-4-cyanopyrazoles, by a Friedländer type reaction, is described. Their structures were confirmed by 1H and 13C NMR spectroscopy, elemental analysis and/or mass spectrometry.

Detalhes bibliográficos
Autor principal:	Rodrigues, Lígia M. (author)
Outros Autores:	Francisco, Carla Santana (author), Campos, Ana M. F. Oliveira (author), Salaheldin, Abdellatif M. (author)
Formato:	article
Idioma:	eng
Publicado em:	2008
Assuntos:	Alzheimer’s disease Friedländer reaction Aminocyanopyrazole, Niitrogen heterocycles Tacrine analogues, Friedlander reaction nitrogen heterocycles tacrine analogs Science & Technology
Texto completo:	http://hdl.handle.net/1822/12596
País:	Portugal
Oai:	oai:repositorium.sdum.uminho.pt:1822/12596

Descrição
Resumo:	Synthesis of eleven tacrine analogues derived from N-aryl-5-amino-4-cyanopyrazoles, by a Friedländer type reaction, is described. Their structures were confirmed by 1H and 13C NMR spectroscopy, elemental analysis and/or mass spectrometry.