Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models

Machado-Joseph disease (MJD) is a neurodegenerative disorder caused by an abnormal expansion of citosine-adenine-guanine trinucleotide repeats in the disease-causing gene. This mutation leads to an abnormal polyglutamine tract in the protein ataxin-3 (Atx3), resulting in formation of mutant Atx3 agg...

Full description

Bibliographic Details
Main Author: Marcelo, Adriana (author)
Other Authors: Brito, Filipa (author), Carmo-Silva, Sara (author), Matos, Carlos A. (author), Alves-Cruzeiro, Joao (author), Vasconcelos-Ferreira, Ana (author), Koppenol, Rebekah (author), Mendonca, Liliana (author), de Almeida, Luis Pereira (author), Nóbrega, Clévio (author)
Format: article
Language:eng
Published: 2020
Subjects:
Mutant Ataxin-3
Rat Model
Protein
Neuropathology
Hepatotoxicity
Online Access:http://hdl.handle.net/10400.1/14482
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/14482

Internet

http://hdl.handle.net/10400.1/14482

Similar Items