Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormon...

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Detalhes bibliográficos
Autor principal: Vaz-Silva, João (author)
Outros Autores: Gomes, Patrícia (author), Jin, Qi (author), Zhu, Mei (author), Zhuravleva, Viktoriya (author), Quintremil, Sebastian (author), Meira, Torcato Duarte Novo (author), Silva, Joana (author), Dioli, Chrysoula (author), Cunha, Carina Isabel Soares (author), Daskalakis, Nikolaos P. (author), Sousa, Nuno (author), Sotiropoulos, I. (author), Waites, Clarissa L. (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
endolysosomal
ESCRT
glucocorticoid
Rab35
Tau
Ciências Médicas::Medicina Básica
Science & Technology
Texto completo:http://hdl.handle.net/1822/57955
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/57955

Texto Completo

http://hdl.handle.net/1822/57955

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