Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction

Emerging studies implicate Tau as an essential mediator of neuronal atrophy and cognitive impairment in Alzheimer's disease (AD), yet the factors that precipitate Tau dysfunction in AD are poorly understood. Chronic environmental stress and elevated glucocorticoids (GC), the major stress hormon...

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Bibliographic Details
Main Author: Vaz-Silva, João (author)
Other Authors: Gomes, Patrícia (author), Jin, Qi (author), Zhu, Mei (author), Zhuravleva, Viktoriya (author), Quintremil, Sebastian (author), Meira, Torcato Duarte Novo (author), Silva, Joana (author), Dioli, Chrysoula (author), Cunha, Carina Isabel Soares (author), Daskalakis, Nikolaos P. (author), Sousa, Nuno (author), Sotiropoulos, I. (author), Waites, Clarissa L. (author)
Format: article
Language:eng
Published: 2018
Subjects:
endolysosomal
ESCRT
glucocorticoid
Rab35
Tau
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/57955
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/57955

Internet

http://hdl.handle.net/1822/57955

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