The Cryptococcus neoformans monocarboxylate transporter Jen4 is responsible for increased 3-bromopyruvate sensitivity

In the last decades, 3-bromopyruvate (3BP) has been intensively studied as a promising anticancer and antimicrobial agent. The transport of this drug inside the cell is a critical step for its toxicity in cancer and microorganisms. The Cryptococcus neoformans is the most sensitive species of microor...

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Bibliographic Details
Main Author: Niedzwiecka, Katarzyna (author)
Other Authors: Ribas, David (author), Casal, Margarida (author), Ulaszewski, Stanislaw (author)
Format: article
Language:eng
Published: 2019
Subjects:
Cryptococcus neoformans
yeast
3-bromopyruvate
heterologous expression
monocarboxylic acid transporters
Jen1 lactate transporter family
Ciências Naturais::Ciências Biológicas
Science & Technology
Online Access:http://hdl.handle.net/1822/73112
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73112

Internet

http://hdl.handle.net/1822/73112

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