The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH

Although the anti-cancer properties of 3BP have been described previously, its selectivity for cancer cells still needs to be explained. In the work reported here we characterized the kinetic parameters of radiolabelled [14C]-3BP uptake in three breast cancer cell lines that display different levels...

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Bibliographic Details
Main Author: Silva, João Sérgio Azevedo Lima (author)
Other Authors: Queirós, Odília (author), Ribeiro, Ana (author), Baltazar, Fátima (author), Ko H. Young (author), Pedersen, Peter L. (author), Preto, Ana (author), Casal, Margarida (author)
Format: article
Language:eng
Published: 2015
Subjects:
3-bromopyruvate
Cluster of differentiation (CD) 147
Extracellular acid pH
Lactate
Monocarboxylate transporter
Tumour microenvironment
Science & Technology
Online Access:http://hdl.handle.net/1822/42779
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/42779

Internet

http://hdl.handle.net/1822/42779

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