Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis

Aim: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HC), induced by these compounds. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC. M...

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Detalhes bibliográficos
Autor principal: Macedo, Francisco Yuri Bulcão (author)
Outros Autores: Baltazar, Fátima (author), Mourão, Lívia Cajaseiras (author), Almeida, Paulo Roberto Carvalho (author), Mota, José Mauricio S. C. (author), Schmitt, Fernando C. (author), Ribeiro, Ronaldo A. (author)
Formato: article
Idioma:eng
Publicado em: 2008
Assuntos:
Acrolein
Administration, Intravesical
Animals
Cyclooxygenase-2
Cystitis
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Induction
Hemorrhage
Male
Organ Size
Rats
Rats, Wistar
Time Factors
Urinary Bladder
Hemorrhagic cystitis
Science & Technology
Texto completo:http://hdl.handle.net/1822/61605
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/61605

Texto Completo

http://hdl.handle.net/1822/61605

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