Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5-a] pyridine-fused steroids

Regio-and stereoselective synthesis of novel chiral 4,5,6,7-tetrahydropyrazolo [1,5-a]pyridine fused steroids via [8 pi + 2 pi] cycloaddition of diazafulvenium methides with steroidal scaffolds is reported. The biological evaluation of the new family of hexacyclic steroids as anti-cancer agents was...

Full description

Bibliographic Details
Main Author: Lopes, Susana M. M. (author)
Other Authors: Sousa, Emanuel P. (author), Barreira, Luísa (author), F. Marques, C. (author), Rodrigues, Maria João (author), Pinho e Melo, Teresa M. V. D. (author)
Format: article
Language:eng
Published: 2019
Subjects:
C-17 pyrazolinyl derivatives
Diazafulvenium methides
Prostate-cancer
Proliferation
Online Access:http://hdl.handle.net/10400.1/13108
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13108

Internet

http://hdl.handle.net/10400.1/13108

Similar Items