Cannabinoid modulation of limbic forebrain noradrenergic circuitry

Both the endocannabinoid and noradrenergic systems have been implicated in neuropsychiatric disorders. Importantly, low levels of norepinephrine are seen in patients with depression, and antagonism of the cannabinoid receptor type 1 (CB1R) is able to induce depressive symptoms in rodents and humans....

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Bibliographic Details
Main Author: Carvalho, Ana Raquel Franky Gomes (author)
Other Authors: Mackie, Kenneth (author), Van Bockstaele, Elisabeth J. (author)
Format: article
Language:eng
Published: 2010
Subjects:
Animals
Benzoxazines
Calcium channel blockers
Cannabinoid receptor modulators
Cannabinoids
Humans
Male
Morpholines
Naphthalenes
Neurons
Norepinephrine
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1
Receptors, Adrenergic, alpha-2
Receptors, Adrenergic, beta-1
Synapses
Limbic system
Neural pathways
Prosencephalon
adrenergic receptor
cannabinoid receptor type 1
nucleus accumbens
nucleus of the solitary tract
Sprague-Dawley
Science & Technology
Online Access:http://hdl.handle.net/1822/67527
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67527

Internet

http://hdl.handle.net/1822/67527

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