Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Transcriptional deregulation and changes in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been described in Huntington's disease (HD). We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A and sodium butyrate (SB) ameliorate...

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Detalhes bibliográficos
Autor principal: Naia, Luana (author)
Outros Autores: Cunha-Oliveira, Teresa (author), Rodrigues, Joana (author), Rosenstock, Tatiana R. (author), Oliveira, Ana (author), Ribeiro, Márcio (author), Carmo, Catarina (author), Oliveira-Sousa, Sofia I. (author), Duarte, Ana I. (author), Hayden, Michael R. (author), Rego, A. Cristina (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
Animals
Cells, Cultured
Enzyme Activation
Histone Deacetylase Inhibitors
Huntington Disease
Male
Mice
Mitochondria
Neurons
Neuroprotective Agents
Pyruvate Dehydrogenase Complex
Treatment Outcome
Texto completo:http://hdl.handle.net/10316/44843
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/44843

Texto Completo

http://hdl.handle.net/10316/44843

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