Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Transcriptional deregulation and changes in mitochondrial bioenergetics, including pyruvate dehydrogenase (PDH) dysfunction, have been described in Huntington's disease (HD). We showed previously that the histone deacetylase inhibitors (HDACIs) trichostatin A and sodium butyrate (SB) ameliorate...

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Bibliographic Details
Main Author: Naia, Luana (author)
Other Authors: Cunha-Oliveira, Teresa (author), Rodrigues, Joana (author), Rosenstock, Tatiana R. (author), Oliveira, Ana (author), Ribeiro, Márcio (author), Carmo, Catarina (author), Oliveira-Sousa, Sofia I. (author), Duarte, Ana I. (author), Hayden, Michael R. (author), Rego, A. Cristina (author)
Format: article
Language:eng
Published: 2017
Subjects:
Animals
Cells, Cultured
Enzyme Activation
Histone Deacetylase Inhibitors
Huntington Disease
Male
Mice
Mitochondria
Neurons
Neuroprotective Agents
Pyruvate Dehydrogenase Complex
Treatment Outcome
Online Access:http://hdl.handle.net/10316/44843
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/44843

Internet

http://hdl.handle.net/10316/44843

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