A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

Glioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemothe...

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Bibliographic Details
Main Author: Pojo, Marta (author)
Other Authors: Gonçalves, Céline S. (author), Magalhães, Ana Xavier (author), Oliveira, Ana Isabel (author), Gonçalves, Tiago (author), Correia, Sara (author), Rodrigues, Ana João (author), Costa, Sandra Maria Araújo da (author), Pinto, Luísa (author), Pinto, Afonso A. (author), Lopes, José M. (author), Reis, R. M. (author), Rocha, Miguel (author), Sousa, Nuno (author), Costa, Bruno Marques (author)
Format: article
Language:eng
Published: 2015
Subjects:
Glioblastoma
Prognosis
Oncogene
Temozolomide
HOXA9
Science & Technology
Online Access:http://hdl.handle.net/1822/35090
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/35090

Internet

http://hdl.handle.net/1822/35090

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