A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

Glioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemothe...

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Detalhes bibliográficos
Autor principal: Pojo, Marta (author)
Outros Autores: Gonçalves, Céline S. (author), Magalhães, Ana Xavier (author), Oliveira, Ana Isabel (author), Gonçalves, Tiago (author), Correia, Sara (author), Rodrigues, Ana João (author), Costa, Sandra Maria Araújo da (author), Pinto, Luísa (author), Pinto, Afonso A. (author), Lopes, José M. (author), Reis, R. M. (author), Rocha, Miguel (author), Sousa, Nuno (author), Costa, Bruno Marques (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Glioblastoma
Prognosis
Oncogene
Temozolomide
HOXA9
Science & Technology
Texto completo:http://hdl.handle.net/1822/35090
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/35090

Texto Completo

http://hdl.handle.net/1822/35090

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