The mechanism through which translation-termination codons are recognized as premature

About one third of the gene mutations found in human genetic disorders, including cancer, result in premature termination codons (PTCs) and the rapid degradation of their mRNAs by nonsense-mediated decay (NMD). NMD controls the quality of eukaryotic gene expression. The strength of the NMD response...

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Detalhes bibliográficos
Autor principal: Onofre, Claudia (author)
Outros Autores: Menezes, Juliane (author), Peixeiro, Isabel (author), Barbosa, Cristina (author), Romão, Luísa (author)
Formato: conferenceObject
Idioma:eng
Publicado em: 2017
Assuntos:
Nonsense-mediated Decay (NMD)
Human Genetic Disorders
mRNA Translation
Expressão Génica
Genómica Funcional e Estrutural
Texto completo:http://hdl.handle.net/10400.18/5133
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5133

Texto Completo

http://hdl.handle.net/10400.18/5133

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