Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition and potential impact on p53

The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well...

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Bibliographic Details
Main Author: Long, Solida (author)
Other Authors: Loureiro, Joana B. (author), Carvalho, Carla (author), Gales, Luís (author), Saraiva, Lucília (author), Pinto, Madalena M. M. (author), Puthongking, Ploenthip (author), Sousa, Emília (author)
Format: article
Language:eng
Published: 2021
Subjects:
Aminocarbazoles
Heptaphylline
Alkaloids
Tumor
p53
Mutant
Online Access:http://hdl.handle.net/1822/73355
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/73355

Internet

http://hdl.handle.net/1822/73355

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