In Vitro Evaluation of Novel Reverse Transcriptase Inhibitors TAF (Tenofovir Alafenamide) and OBP-601 (2,3-Didehydro-3-Deoxy-4-Ethynylthymidine) Against Multi-Drug Resistant Primary Isolates of HIV-2

New antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients exp...

ver descrição completa

Detalhes bibliográficos
Autor principal: Bártolo, I (author)
Outros Autores: Borrego, P (author), Gomes, P (author), Gonçalves, F (author), Caixas, U (author), Pinto, I (author), Taveira, N (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
HSJ MED
Humans
Adenine / analogs & derivatives
Adenine / pharmacology
Anti-HIV Agents / pharmacology
Drug Discovery
Drug Resistance, Multiple, Viral
HIV-2 / drug effects
Mutation
Microbial Sensitivity Tests
Reverse Transcriptase Inhibitors / pharmacology
Virus Replication / drug effects
Texto completo:http://hdl.handle.net/10400.17/3819
País:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/3819

Texto Completo

http://hdl.handle.net/10400.17/3819

Registos relacionados