The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

14834). Received by CS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Fundacao para a Ciencia e Tecnologia https://www.fct.pt/index.phtml.en (grant number SFRH/BPD/41416/2007; SFRH/BPD/64702/2009; SFRH/BPD/109347/2015; SF...

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Detalhes bibliográficos
Autor principal: de Oliveira, R.M. (author)
Outros Autores: Vicente Miranda, H. (author), Francelle, L. (author), Pinho, R. (author), Szegö, É.M. (author), Martinho, R. (author), Munari, F. (author), Lázaro, D.F. (author), Moniot, S. (author), Guerreiro, P. (author), Fonseca, L. (author), Marijanovic, Z. (author), Antas, P. (author), Gerhardt, E. (author), Enguita, F.J. (author), Fauvet, B. (author), Penque, D. (author), Pais, T.F. (author), Tong, Q. (author), Becker, S. (author), Kügler, S. (author), Lashuel, H.A. (author), Steegborn, C. (author), Zweckstetter, M. (author), Outeiro, T.F. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
1,2,3,6 tetrahydro 1 methyl 4 phenylpyridine
alpha synuclein
lysine
protein aggregate
protein binding
sirtuin 2
acetylation
animal
autophagy
brain cortex
C57BL mouse
cell culture
cell membrane
disease model
dopaminergic nerve cell
drug effects
gene deletion
gene silencing
genetics
HEK293 cell line
human
knockout mouse
metabolism
mutation
neuroprotection
Parkinson disease
pathology
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Acetylation
alpha-Synuclein
Animals
Autophagy
Cell Membrane
Cells, Cultured
Cerebral Cortex
Disease Models, Animal
Dopaminergic Neurons
Gene Deletion
Gene Knockdown Techniques
HEK293 Cells
Humans
Lysine
Mice, Inbred C57BL
Mice, Knockout
Mutation
Neuroprotection
Parkinson Disease
Protein Aggregates
Protein Binding
Sirtuin 2
SDG 3 - Good Health and Well-being
Texto completo:https://doi.org/10.1371/journal.pbio.2000374
País:Portugal
Oai:oai:run.unl.pt:10362/24648

Texto Completo

https://doi.org/10.1371/journal.pbio.2000374

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