Chenodeoxycholate induction of mitochondrial permeability transition pore is associated with increased membrane fluidity and cytochrome c release: protective role of carvedilol

Chenodeoxycholate (CDCA) is a primary bile acid mostly implicated in cholestatic liver injury. In this study, we have investigated the involvement of membrane fluidity and cytochrome c release in CDCA-induced mitochondrial permeability transition (MPT), and the preventive role of carvedilol. Treatme...

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Detalhes bibliográficos
Autor principal: Rolo, Anabela P. (author)
Outros Autores: Oliveira, Paulo J. (author), Moreno, António J. (author), Palmeira, Carlos M. (author)
Formato: article
Idioma:eng
Publicado em: 2003
Assuntos:
Chenodeoxycholate
Carvedilol
Mitochondria
Cholestasis
Cardiomyopathy
Mitochondrial permeability transition
Membrane fluidity
Texto completo:http://hdl.handle.net/10316/5405
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5405

Texto Completo

http://hdl.handle.net/10316/5405

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