Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties

BACKGROUND: The purpose of this study was to investigate some of the possible mechanisms underlying the protective effects of a dipeptidyl peptidase IV (DPP-IV) inhibitor, sitagliptin, on pancreatic tissue in an animal model of type 2 diabetes mellitus (T2DM), the Zucker Diabetic Fatty(ZDF) rat, foc...

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Bibliographic Details
Main Author: Mega, C. (author)
Other Authors: Vala, Helena (author), Rodrigues-Santos, P. (author), Oliveira, J. (author), Teixeira, F. (author), Fernandes, R. (author), Reis, F. (author), Lemos, ET (author)
Format: article
Language:eng
Published: 2015
Subjects:
Type 2 diabetes
Endocrine and exocrine pancreas lesions
Sitagliptin
Cytoprotective properties
ZDF rat
Online Access:http://hdl.handle.net/10400.19/2724
Country:Portugal
Oai:oai:repositorio.ipv.pt:10400.19/2724

Internet

http://hdl.handle.net/10400.19/2724

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