Mild two-step conversion of primary amides to alcohols by reduction of acylimidodicarbonates with sodium borohydride
Di-tert-butyl acylimidodicarbonates, prepared from primary amides with two equivalents of di-tert-butyl dicarbonate under catalysis by 4-dimethylaminopyridine, readily undergo selective reductive cleavage of their acyl CO-N bonds by NaBH4 to provide the corresponding alcohols in high yields.
| Autor principal: | |
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| Outros Autores: | , , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2003
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| Assuntos: | |
| Texto completo: | http://hdl.handle.net/1822/72929 |
| País: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/72929 |