O-mannosylation and N-glycosylation: Two coordinated mechanisms regulating the tumour suppressor functions of E-cadherin in cancer

Dysregulation of tumor suppressor protein E-cadherin is an early molecular event in cancer. O-mannosylation profile of E-cadherin is a newly-described posttranslational modification crucial for its adhesive functions in homeostasis. However, the role of O-mannosyl glycans in E-cadherin-mediated cell...

Full description

Bibliographic Details
Main Author: Carvalho, S (author)
Other Authors: Oliveira, T (author), Bartels, M (author), Miyoshi, E (author), Pierce, M (author), Taniguchi, N (author), Carneiro, F (author), Seruca, R (author), Reis, CA (author), Strahl, S (author), Pinho, SS (author)
Format: article
Language:eng
Published: 2016
Subjects:
Adenocarcinoma/metabolism
Adenocarcinoma/pathology
Animals
Cadherins/metabolism
Glycosylation
Humans
Mannose/metabolism
Mice
Mice, Transgenic
Polysaccharides
Protein Processing, Post-Translational/physiology
Stomach Neoplasms/metabolism
Stomach Neoplasms/pathology
Tumor Suppressor Proteins/metabolism
Online Access:https://repositorio-aberto.up.pt/handle/10216/118210
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/118210

Internet

https://repositorio-aberto.up.pt/handle/10216/118210

Similar Items